| Product Name | CYP2R1 Antibody (H-100) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-100 of CYP2R1 of human origin |
| Modification Notes | P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. There are currently 57 known active cytochrome P450 (CYP) genes and 58 known pseudogenes present in the human genome. CYP2R1 is a 501 amino acid protein which belongs to the CYP2 family of cytochrome P450 proteins. These proteins are usually involved in the metabolism of foreign compounds. CYP2R1 acts as a major vitamin D 25-hydroxylase. A homozygous mutation in the CYP2R1 gene eliminates the vitamin D3 25-hydroxylase activity of the CYP2R1 protein, causing 25-hydroxyvitamin D3 deficiency. Manifestations of 25-hydroxyvitamin D3 deficiency include abnormally low plasma levels of 25-hydroxyvitamin D3 and various symptoms of vitamin D deficiency, including skeletal abnormalities, hypophosphatemia and hypocalcemia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CYP2R1 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-100 of CYP2R1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-100 of CYP2R1 of human origin |
| Entrez Gene | 120227 |
|---|
| Application Notes | recommended for detection of CYP2R1 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
