Application
Western blot analysis of ZKSCAN3 expression in fetal kidney tissue extract.| Product Name | ZKSCAN3 Antibody (B-24) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against ZKSCAN3 of human origin |
| Modification Notes | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZKSCAN3 (Zinc finger protein with KRAB and SCAN domains 3), also known as ZNF306/309 or ZNF47 homolog, is a 583 amino acid protein that may be involved in the regulation of transcription. Belonging to the Krüppel C2H2-type zinc-finger protein family, ZKSCAN3 contains seven C2H2-type zinc fingers, one KRAB domain and one SCAN box domain. Overexpression of ZKSCAN3 has been found in colorectal tumor samples, with higher levels of expression found in invasive tumor types compared with non-invasive tumors. This evidence also coincides with the fact that the chromosomal region of the gene encoding ZKSCAN3 is found to be amplified in colorectal cancer. Knockdown of the mRNA encoding ZKSCAN3 results in impaired anchorage-independent growth and orthotopic tumor growth in two independent colon cancer cell lines. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of ZKSCAN3 of human origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against ZKSCAN3 of human origin |
|---|---|
| Tissue Specificity | raised against ZKSCAN3 of human origin |
| Entrez Gene | 80317 |
|---|
Application
Western blot analysis of ZKSCAN3 expression in fetal kidney tissue extract.| Application Notes | recommended for detection of ZKSCAN3 of human origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
