Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines and cationic drugs as well as other exogenous xenobiotics. The structure of OCT family member proteins consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT6 is highly expressed in testis and fetal liver. OCT6 also displays high expression in human hematopoietic tissues, including CD34+ cells and leukemias making OCT6 a potential therapeutic target for the treatment of leukemia.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAIFIHCIPWB
recommended for detection of OCT6 of human origin by WB, IP, IF, IHC(P) and ELISA: WB:1:50~1:100 IP:1:10~1:50 IHC(P):1:10~1:50 IF:1:10~1:50 ELISA:1:500~2000
Western blot analysis of OCT6 expression in Hep G2 whole cell lysate.
Application Notes
recommended for detection of OCT6 of human origin by WB, IP, IF, IHC(P) and ELISA: WB:1:50~1:100 IP:1:10~1:50 IHC(P):1:10~1:50 IF:1:10~1:50 ELISA:1:500~2000
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.