| Product Name | Fc ε RIα Antibody (M-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 136-205 mapping within an extracellular domain of Fc ε RIα of mouse origin |
| Modification Notes | IgE Fc Receptor I binds to the Fc region of immunoglobulin e chain with high affinity, and is responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators such as histamines, responsible for the manifestations of allergy. IgE Fc Receptor I also induces the secretion of important lymphokines, effectors of the hypersensitivity response. Receptor I is a tetramer of a heavily glycosylated å chain (Fc é RIå), ∫ chain and two disulfide linked © chains. Fc é RIå is exposed to the outer surface of the cell and contains the IgE binding site. Expression of IgE Fc RI mRNA appears to be highly specific and has been identified in mast cells and IL-3 dependent myeloid-monocyte precursor. Alternative splicing of the genomic transcript for the a chain has also been identified. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Fc ε RIα of mouse origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 136-205 mapping within an extracellular domain of Fc &epsilon RI&alpha of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 136-205 mapping within an extracellular domain of Fc ε RIα of mouse origin |
| Entrez Gene | 14125 |
|---|
| Application Notes | recommended for detection of Fc ε RIα of mouse origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
