| Product Name | Sel-1L Antibody (H-57) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 417-473 mapping within an internal region of Sel-1L of human origin |
| Modification Notes | Sel-1L resides mainly in the cytoplasm but also in the nuclei of normal pancreas cells. It has antiproliferative properties with the ability to hinder tumor cell growth in human breast, pancreas, esophageal, and prostate cancers. Sel-1L does this by remodeling the extracellular matrix which creates a microenvironment that is unfavorable to invasive growth. It may also play a role in TGF-beta signaling. Approximately two thirds of breast tumors exhibit drastic downregulation or absence of Sel-1L expression, which causes the cell-matrix interactions and collagen binding to be disrupted. It has been hypothesized that Sel-1L may mediate cellular changes that promote the transition from a normal mucosa to a neoplastic lesion, suggesting that Sel-1L may be useful identifying patients who have a high risk of developing cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Sel-1L of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 417-473 mapping within an internal region of Sel-1L of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 417-473 mapping within an internal region of Sel-1L of human origin |
| Application Notes | recommended for detection of Sel-1L of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
