Members of the leucine-rich repeat family include LRCH1, LRCH2, LRCH3 and LRCH4. All family members contain one calponin-homology domain and nine leucine-rich repeats. The gene encoding LRCH1, also known as Neuronal protein 81 (NP81), has been suggested to be a possible gene locus for susceptibility to osetoarthritis, especially in women, though studies have shown conflicting results. LRCH1 is a 728 amino acid protein that is expressed at highest levels in cerebellum, with lower levels of expression in spinal cord, ovary, kidney and amygdala. In pigs, the gene encoding LRCH1 is one of 22 genes that is associated with leg and body conformation traits that affect productivity and health. There are two isoforms of LRCH1 that are expressed as a result of alternative splicing events.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of LRCH1 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with LRCH1-b, LRCH1-a also reactive with additional species, including equine
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope mapping at the N-terminus of LRCH1 of human origin
Tissue Specificity
epitope mapping at the N-terminus of LRCH1 of human origin
Western blot analysis of LRCH1 expression in HeLa whole cell lysate.
Application Notes
recommended for detection of LRCH1 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with LRCH1-b, LRCH1-a also reactive with additional species, including equine
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.