| Product Name | IL-1RAcP Antibody (H-128) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Interleukin-1 (IL-1) is a key pro-inflammatory cytokine that has diverse actions in the brain as a regulator of host defense responses and a mediator of inflammation. Two major agonists, IL-1å and IL-1∫, bind to a single known functional type-1 IL-1 receptor (IL-1RI), which associates with the accessory protein (IL-1RAcP), resulting in signal transduction. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1RAcP to activate NF˚B. The membrane bound form of IL-1RAcP (mIL-1RAcP) facilitates signal transduction. Two alternatively spliced isoforms, soluble IL-1RAcP (sIL-1RAcP) and sIL-1RAcP-∫, which lack transmembrane and intracellular domains, can inhibit IL-1 signaling. Although both mIL-1RAcP and sIL-1RAcP mRNAs are widely expressed in human tissue, their relative proportions differ significantly in a tissue-specific manner. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of IL-1RAcP of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 221-348 mapping within an internal region of IL-1RAcP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 221-348 mapping within an internal region of IL-1RAcP of human origin |
| Entrez Gene | 3556 |
|---|
| Application Notes | recommended for detection of IL-1RAcP of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
