| Modification Notes |
The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. SLC10A6 (solute carrier family 10, member 6), also known as SOAT (sodium-dependent organic anion transporter), is a 373 amino acid multi-pass membrane protein belonging to the sodium:bile acid symporter family. Highly expressed in testis, placenta and pancreas, SLC10A6 transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. SLC10A6 plays an important role in the cellular delivery of specific prohormones in testis, placenta, adrenal gland and other peripheral tissues. SLC10A6 has nine transmembrane domains, with an N-terminus outside the cell and an intracellular C-terminus. |