| Product Name | MAT II Antibody (H-48) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 43-90 mapping at the N-terminus of MAT II of human origin |
| Modification Notes | Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosyltransferase (AdoMet) for methionine catabolism in the liver. Two different genes, MAT1A and MAT2A, encode a liver specific and non-liver specific form of MAT, respectively. Inactivation of the liver specific gene product, designated MAT I/III, associates with liver diseases such as cirrhosis. MAT1A expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT2A present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NF-kB and TNFå cause a switch from MAT1A to MAT2A expression in human hepatocellular carcinoma (HCC), which facilitates cancer cell growth. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MAT II of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 43-90 mapping at the N-terminus of MAT II of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 43-90 mapping at the N-terminus of MAT II of human origin |
| Application Notes | recommended for detection of MAT II of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
