Myotubularin and the myotubularin-related proteins belong to a highly conserved family of eukaryotic phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR8 (myotubularin related protein 8) is a 704 amino acid protein that localizes to the nuclear envelope and is a member of the protein-tyrosine phosphatase family and non-receptor class myotubularin subfamily. Existing as two alternatively spliced isoforms, MTMR8 contains one myotubularin phosphatase domain and functions as a phosphatase that targets lipids containing phosphoinositol headgroups. The gene encoding MTMR8 maps to human chromosome X, which consists of about 153 million base pairs and nearly 1,000 genes. Color blindness, hemophilia and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently, as males carry a single X chromosome.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of MTMR9 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 1-180 mapping at the N-terminus of MTMR9 of human origin
Tissue Specificity
epitope corresponding to amino acids 1-180 mapping at the N-terminus of MTMR9 of human origin
Application
Application
Western blot analysis of MTMR9 expression in non-transfected (A) and human MTMR9 transfected (B) CMV whole cell lysates.
Application Notes
recommended for detection of MTMR9 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.