| Product Name | CARMIL Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | CARMIL, also referred to as Leucine-rich repeat containing 16 (LRRC16), is a member of a recently described family of leucine-rich repeat containing proteins which have a variety of functions throughout the body. CARMIL interacts with the Arp2/3 complex, the Actin capping protein CP and Myosin I to help assemble a multi-protein structure that is crucial to proper cell development. Through its interactions with these three proteins, CARMIL regulates capping of Actin filaments at the barbed end, nucleation of Actin by the Arp2/3 complex and Actin filament assembly by Myosin I, a barbed-end directed motor. Together, this complex generates the force for diverse cellular movements such as cytokinesis, phag-ocytosis and muscle contraction. Defects in the gene encoding CARMIL are thought to have various detrimental effects including reduced chemotactic aggregation, lowered rates of pinocytosis and inefficient assembly of the Myosin-Arp2/3-CP complex. Without proper CARMIL function, cell development is retarded due to improper Actin filament assembly. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CARMIL, also designated Leucine rich repeat containing 16, of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 662-961 mapping within an internal region of CARMIL of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 662-961 mapping within an internal region of CARMIL of human origin |
| Entrez Gene | 55604 |
|---|
| Application Notes | recommended for detection of CARMIL, also designated Leucine rich repeat containing 16, of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
