| Modification Notes |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF35 (zinc finger protein 35), also known as HF.10, HF10 or Zfp105, is a zinc finger protein that localizes to the nucleus and belongs to the Krüppel C2H2-type zinc finger protein family. ZNF35 contains 11 C2H2-type zinc fingers and may play a role in transcriptional regulation as well as cell differentiation and proliferation. The gene encoding ZNF35 maps to chromosome 3 in the region often involved in deletions or karyotypic rearrangements that have been associated with a variety of tumors including renal and lung carcinoma. The mouse homolog of ZNF35, Zfp105, is highly expressed in testis, particularly in round spermatids and pachytene spermatocytes. |
