| Product Name | Kremen-1 Antibody (H-48) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The Wnt genes are a group of well conserved, cysteine-rich secreted glycoproteins that are required for numerous developmental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patterning. The association of the Wnt protein with the seven membrane spanning receptor frizzled activates dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation. Reduced levels of active GSK causes the accumulation of b-catenin and subsequent regulation of developmentally significant Wnt target genes. Wnt antagonists, Dickkopf (which includes Dkk1-4), frizzled-related protein (sFRP), Soggy-1, Kremen-1 and Wnt inhibitory factor-1 (WIF-1) are necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Kremen-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 265-312 mapping within an internal region of Kremen-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 265-312 mapping within an internal region of Kremen-1 of human origin |
| Entrez Gene | 83999 |
|---|
| Application Notes | recommended for detection of Kremen-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
