| Product Name | Perp Antibody (FL-193) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The Perp protein, also known as p53 (apoptosis) effector related to PMP22, keratinocytes-associated protein 1 (KCP 1), p53-induced protein PIGPC1 or transmembrane protein THW, contains 193 amino acids and has four transmembrane domains, two extracellular domains and three cytoplasmic domains. Northern blot analysis using a multiple tissue array demonstrates that Perp is predominantly expressed in esophagus and trachea tissues. Perp is required for the integrity of the stratified epithelia defined by p63 (a tumor suppressor gene); expression of Perp in these structures is contingent on the presence of p63. The position of Perp downstream of p63 and p53, as well as its essential role in regular desmosome function, suggest that it, like other adhesion proteins, may be a target for mutation in human blistering diseases or cancer. Furthermore, research demonstrates that the downregulation of Perp correlates with meta-static capacity of human melanoma cell lines, indicating that Perp may be a tumor suppressor. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Perp of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-193 representing full length Perp of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-193 representing full length Perp of human origin |
| Entrez Gene | 64065 |
|---|
| Application Notes | recommended for detection of Perp of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
