| Product Name | ICA69 Antibody (H-46) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Pancreatic islet cells are clusters of endocrine cells that are scattered throughout the tissue of the pancreas and secrete insulin and glucagon, which help the body store and use sugars. Each islet contains approximately 1,000 cells and is 50-500 µm in diameter. Islet cell autoantigen 1, also designated ICA69 or p69 protein, is an environmental trigger molecule that induces diabetic autoimmunity to insulin producing islet cells. The human ICA1 gene maps to chromosome 7p22 and generates three transcript variants that encode the T cell epitope (in exon 2) that is detectable by autoreactive T cells in diabetic children. Human ICA69 transcript is abundant in pancreas, brain and heart, with lower levels of expression found in lung, liver, thyroid and kidney. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ICA69 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 223-268 mapping within an internal region of ICA69 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 223-268 mapping within an internal region of ICA69 of human origin |
| Application Notes | recommended for detection of ICA69 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
