Application
Western blot analysis of ZNF74 expression in Jurkat nuclear extract.| Product Name | ZNF74 Antibody (C-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF74 (Zinc finger protein 74) is a 643 amino acid nuclear protein that contains one KRAB domain and twelve C2H2-type zinc fingers. These internal features enable ZNF74 to bind tightly to the nuclear matrix and be involved in protein-protein interactions. Mapping to chromosome 22, the gene encoding ZNF74 is found to be consistently deleted in DiGeorge syndrome, a disease characterized by congenital heart defects, recurrent infections, palate abnormalities and learning disabilities. There are four isoforms of ZNF74 that are produced as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ZNF74 of human origin by WB, IP, IF and ELISA non cross-reactive with other ZNF family members | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of ZNF74 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of ZNF74 of human origin |
| Entrez Gene | 7625 |
|---|
Application
Western blot analysis of ZNF74 expression in Jurkat nuclear extract.| Application Notes | recommended for detection of ZNF74 of human origin by WB, IP, IF and ELISA non cross-reactive with other ZNF family members |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
