| Product Name | Neuregulin-3 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The ErbB/HER family of receptor tyrosine kinases consists of four receptors that bind a large number of growth factor ligands sharing an epidermal growth factor-(EGF)-like motif. The neuregulins (NRGs) are a diverse family of proteins that arise by alternative splicing from a single gene. These proteins play an important role in controlling the growth and differentiation of glial, epithelial, and muscle cells. Whereas ErbB-1 binds seven different ligands whose prototype is EGF, the four families of neuregulins activate ErbB-3 and/or ErbB-4. Neuregulin-1 (also known as heregulin) has diverse functions in neural development, and one of them is to up-regulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions. Neuregulin-2 exhibits a distinct expression pattern in adult brain and developing heart. Neuregulin-3 is expressed in cell lines derived from breast cancer and is a potential regulator of normal and malignant breast epithelial cells. Neuregulin-4 is detected in the adult pancreas and weakly in muscle. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Neuregulin-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 276-345 mapping within an N-terminal extracellular domain of Neuregulin-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 276-345 mapping within an N-terminal extracellular domain of Neuregulin-3 of human origin |
| Entrez Gene | 10718 |
|---|
| Application Notes | recommended for detection of Neuregulin-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
