Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF35 (zinc finger protein 35), also known as HF.10, HF10 or Zfp105, is a zinc finger protein that localizes to the nucleus and belongs to the Krüppel C2H2-type zinc finger protein family. ZNF35 contains 11 C2H2-type zinc fingers and may play a role in transcriptional regulation as well as cell differentiation and proliferation. The gene encoding ZNF35 maps to chromosome 3 in the region often involved in deletions or karyotypic rearrangements that have been associated with a variety of tumors including renal and lung carcinoma. The mouse homolog of ZNF35, Zfp105, is highly expressed in testis, particularly in round spermatids and pachytene spermatocytes.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of ZNF35 of human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 21-220 mapping near the N-terminus of ZNF35 of human origin
Tissue Specificity
epitope corresponding to amino acids 21-220 mapping near the N-terminus of ZNF35 of human origin