Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kruppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF3, also known as KOX25, is a zinc finger protein belonging to the Kruppel C(2)H(2)-type zinc finger protein family. It localizes to the nucleus and is involved in cell differentiation and proliferation. ZNF3 is a 446 amino acid long protein that contains eight C(2)H(2)-type zinc fingers and one KRAB domain. ZNF3 is located in a cluster of KOX zinc-finger genes found on chromosome 10.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of ZNF3 of human origin by WB, IP, IF and ELISA may cross-react with mouse ZFP113 also reactive with additional species, including equine and canine
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 106-214 mapping within an internal region of ZNF3 of human origin
Tissue Specificity
epitope corresponding to amino acids 106-214 mapping within an internal region of ZNF3 of human origin
Western blot analysis of ZNF3 expression in HeLa whole cell lysate.
Application Notes
recommended for detection of ZNF3 of human origin by WB, IP, IF and ELISA may cross-react with mouse ZFP113 also reactive with additional species, including equine and canine
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.