Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human oral mucosa tissue showing membrane and cytoplasmic staining of squamous epithelial cells.Application
Western blot analysis of AHNAK expression in HL-60 nuclear extract.| Product Name | AHNAK Antibody (H-153) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | AHNAK (Neuroblast differentiation-associated protein AHNAK, Desmoyokin) is a 5,890 amino acid protein encoded by the human gene AHNAK. The intronless AHNAK gene is located on human chromosome 11q12 and has three main structural regions: the 251 amino acid N-terminus, a large central region of 4390 amino acids with multiple repeated units of about 128 amino acids in length, and the 1002 amino acid C-terminus. The central region seems to have antiparallel beta-strands connected by intervening loops. Several putative regulatory elements are clustered within the C-terminal region, including nuclear export localization signals, a leucine zipper, and potential phosphorylation sites for Akt1 and PKC. AHNAK is believed to be an important signalling molecule involved in a wide range of physiological activities and may be required for neuronal cell differentiation.. AHNAK also appears to influence b-adrenergic regulation of cardiac L-type Ca2+ channel function. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of AHNAK of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 5568-5720 mapping near the C-terminus of AHNAK of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 5568-5720 mapping near the C-terminus of AHNAK of human origin |
| Entrez Gene | 79026 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human oral mucosa tissue showing membrane and cytoplasmic staining of squamous epithelial cells.
Application
Western blot analysis of AHNAK expression in HL-60 nuclear extract.| Application Notes | recommended for detection of AHNAK of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
