Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. The gene encoding CCDC14 (Coiled-coil domain-containing protein 14), a 905 amino acid protein, exists on chromosome 3. There are five isoforms of CCDC14 that are produced as a result of alternative splicing events.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of CCDC14 of h and r origin by WB, IP, IF and ELISA non cross-reactive with other CCDC family members also reactive with additional species, including canine and bovine
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope mapping near the N-terminus of CCDC14 of human origin
Tissue Specificity
epitope mapping near the N-terminus of CCDC14 of human origin
Western blot analysis of CCDC14 expression in MCF7 (A), SW480 (B), T84 (C), MDA-MB-231 (D) and Jurkat (E) whole cell lysates.
Application Notes
recommended for detection of CCDC14 of h and r origin by WB, IP, IF and ELISA non cross-reactive with other CCDC family members also reactive with additional species, including canine and bovine
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.