Application
Western blot analysis of PRMT8 expression in K-562 whole cell lysate.Application
Western blot analysis of PRMT8 expression in non-transfected (A) and human PRMT8 transfected (B) 293 whole cell lysates.| Product Name | PRMT8 Antibody (T-21) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMT8, also known as HRMT1L3 or HRMT1L4 (heterogenous nuclear ribonucleioprotein methyltransferase-like protein 4), is a distinct member of the type 1 PRMT family with tissue-specific expression and plasma membrane localization. PRMT8 is specifically expressed in the brain where it functions as an arginine methyltransferase with a possible role in neuronal differentiation. It is most closely related to PRMT1 and may have arisen through a gene duplication. PRMT8 can heterodimerize with PRMT1 and has similar substrate preference. Distinguishing PRMT8 from other PRMT enzymes is its unique N-terminal myristoylation motif, which is responsible for its plasma membrane localization. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of PRMT8 of human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of PRMT8 of human origin by WB, IP and ELISA |
| Entrez Gene | 56341 |
|---|
Application
Western blot analysis of PRMT8 expression in K-562 whole cell lysate.
Application
Western blot analysis of PRMT8 expression in non-transfected (A) and human PRMT8 transfected (B) 293 whole cell lysates.| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
