Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF436 is a 470 amino acid protein belonging to the Krüppel C2H2-type zinc-finger family. ZNF436 may act as a negative regulator in gene transcription mediated by the MAPK signaling pathways. ZNF436 localizes to the nucleus and contains 12 C2H2-type zinc fingers and a KRAB domain. ZNF436 is expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of ZNF436 of human origin by WB, IP and ELISA