| Product Name | DABP Antibody (H-40) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | DABP (D-boxBP, D site-binding protein, Albumin D-element-binding protein, TAXREB302) is a 325 amino acid protein that belongs to the bZIP family (PAR subfamily) and contains one bZIP domain. It functions as a transcriptional activator that recognizes and binds to the promoter sequence 5'-RTTAYGTAAY-3' found in the promoter region of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, however, it does help modulate important clock output genes. DABP may be a direct target for regulation by the circadian pacemaker component Clock. Mice deficient for bZip PAR gene products (such as DABP, EPAS-1 and TEF) are highly susceptible to generalized spontaneous and audiogenic epilepsies. This is likely because bZip PAR targets the gene that encodes pyridoxal kinase. This kinase converts vitamin B6 derivatives into pyridoxal phosphate (PLP) which is a coenzyme for amino acid and neurotransmitter metabolism. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DABP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 35-74 mapping near the N-terminus of DABP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 35-74 mapping near the N-terminus of DABP of human origin |
| Entrez Gene | 1628 |
|---|
| Application Notes | recommended for detection of DABP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
