Application
Western blot analysis of DCAMKL1 expression in non-transfected: (A) and truncated mouse DCAMKL1 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of DCAMKL1 expression in mouse brain tissue extract.| Product Name | DCAMKL1 Antibody (P-25) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to ß-subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortin-like and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of DCAMKL1 of mouse and human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of DCAMKL1 of mouse and human origin by WB, IP and ELISA |
| Entrez Gene | 9201 |
|---|
Application
Western blot analysis of DCAMKL1 expression in non-transfected: (A) and truncated mouse DCAMKL1 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of DCAMKL1 expression in mouse brain tissue extract.| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
