Application
Western blot analysis of TC1 expression in rat thyroid tissue extracts.Application
Western blot analysis of TC1 expression in mouse thyroid tissue extract.| Product Name | TC1 Antibody (C-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | TC1 (thyroid cancer protein 1), whose alternative names include C8orf4 or MGC22806, is a natively disordered and novel tumorigenic protein consisting of 106 amino acids that is known to associate with thyroid, gastric, and breast cancers. TC1 is ubiquitously expressed and may enhance the aggressive behavior of cancers by acting as an upstream regulator involved in positive regulation of the Wnt/∫-catenin signaling pathway. Upregulation of TC1 by mitogens and the ERK1/2 signaling pathway promotes the G(1)- to S-phase transition of the cell cycle. TC1 also plays a role as a novel heat shock response regulator that is upregulated by cellular stresses and heat shock. The gene encoding TC1 maps to human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies including Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome and congenital hypothyroidism. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TC1 of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of TC1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of TC1 of human origin |
| Entrez Gene | 56892 |
|---|
Application
Western blot analysis of TC1 expression in rat thyroid tissue extracts.
Application
Western blot analysis of TC1 expression in mouse thyroid tissue extract.| Application Notes | recommended for detection of TC1 of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
