| Product Name | Wolframin Antibody (H-215) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The Wolframin gene encodes a protein found in endoplasmic reticulum membrane of several tissues including brain, pancreas, lung and placenta. Loss-of-function mutations in both alleles result in Wolfram syndrome (also known as DIDMOAD, an autosomal recessive disorder that causes juvenile diabetes mellitus, diabetes insipidus, optic atrophy and a number of neurological symptoms including deafness, ataxia and peripheral neuropathy. A large number and variety of mutations in this gene, particularly in exon 8, can be associated with Wolfram syndrome. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Wolframin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 655-869 mapping near the C-terminus of Wolframin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 655-869 mapping near the C-terminus of Wolframin of human origin |
| Entrez Gene | 7466 |
|---|
| Application Notes | recommended for detection of Wolframin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
