COBLL1 (Cordon-bleu protein-like 1), also known as COBLR1 or COBL-like 1, is a 1,204 amino acid protein expressed in liver, kidney, pancreas, spinal cord, brain, lung and ovary. The mouse and human COBLL1 proteins share 63% identity. COBLL1 is highly related to Cordon-bleu, a protein involved in midline development that is specifically expressed in the node and its derivatives, including a portion of the neural tube floor plate, the notochord and the dorsal foregut. Both Cordon-bleu and COBLL1 contain a conserved N-terminus with KRAP (lysine, arginine and proline-rich) repeats, a homologous C-terminus with at least one WH2 domain (one in COBLL1 and three in Cordon-bleu) and a divergent central region. Due to the high degree of similarity between COBLL1 and Cordon-bleu, it has been suggested that COBLL1 may functionally compensate for Cordon-bleu in its absence.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFIHCELISA
recommended for detection of COBLL1 of mouse, rat, human and canine origin by WB, IP, IF, IHC(P) and ELISA