| Product Name | ADH8 Antibody (D-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. ADH8, also known as ADHFE1 (alcohol dehydrogenase, iron containing, 1) or HOT, is a 467 amino acid protein that belongs to the iron-containing alcohol dehydrogenase family and localizes to the mitochondrion. Expressed specifically in adult liver, ADH8 functions to catalyze the cofactor-independent oxidation of gamma-hydroxybutyrate to succinic semialdehyde, a reaction that is coupled to the reduction of 2-ketoglutarate to D-2-hydroxyglutarate and occurs at an optimal pH of 7.5. Succinic semialdehyde can then be converted to succinic acid which is used for energy production in the Krebs cycle. Four isoforms of ADH8 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of ADH8 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with other ADH family members also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of ADH8 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of ADH8 of human origin |
| Entrez Gene | 137872 |
|---|
| Application Notes | recommended for detection of ADH8 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with other ADH family members also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
