Application
Western blot analysis of IPCEF1 expression in Hep G2 whole cell lysate.| Product Name | IPCEF1 Antibody (F-22) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | IPCEF1 (interaction protein for cytohesin exchange factors 1), also known as PIP3-E, is a 437 amino acid protein that localizes to both the cytoplasm and the cell membrane and contains one PH domain. Interacting with the guanine nucleotide exchange factors Cytohesin-1, Cytohesin-2, GRP1 and Cytohesin-4, IPCEF1 enhances the guanine nucleotide exchange activity of Cytohesins with ARF6, thereby modifying ARF6 function and playing a role in Actin reorganization and membrane ruffling. Multiple isoforms of IPCEF1 exist due to alternative splicing events. The gene encoding IPCEF1 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of IPCEF1 of human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of IPCEF1 of human origin by WB, IP and ELISA |
| Entrez Gene | 26034 |
|---|
Application
Western blot analysis of IPCEF1 expression in Hep G2 whole cell lysate.| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
