Application
Western blot analysis of Sp110 expression in non-transfected: (A) and truncated mouse Sp110 transfected: (B) 293T whole cell lysates.| Product Name | Sp110 Antibody (M-190) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Sp110 (Speckled 110 kDa), also known as IPR1, VODI, IFI41 (interferon-induced protein 41, 30 kDa) or IFI75 (interferon-induced protein 75, 52 kDa), is a phosphoprotein belonging to the SP-100/SP140 family of nuclear body components. Sp110 contains an HSR domain, a PHD-type zinc finger, a SAND domain and a bromodomain and is believed to function as a transcriptional coactivator of nuclear hormone receptors. Induced by IFN-g and all-trans retinoic acid, Sp110 participates in immunoprotective mechanisms against pathogens. Mutations in the gene encoding SP110 can lead to hepatic venoocclusive disease with immunodeficiency (VODI), a disease characterized by T and B cell immunodeficiency, absent tissue plasma cells, absent lymph node germinal centers and severe hypogammaglobulinemia. Due to alternative splicing events, five isoforms exist for Sp110. Isoform 3, also known as Sp110b, interacts with the Hep C Core Protein. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Sp110 of mouse and rat origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 61-242 mapping near the N-terminus of Sp110 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 61-242 mapping near the N-terminus of Sp110 of mouse origin |
| Entrez Gene | 109032 |
|---|
Application
Western blot analysis of Sp110 expression in non-transfected: (A) and truncated mouse Sp110 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of Sp110 of mouse and rat origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
