Tctex2 (t-complex testis expressed 2) is one of the distorter genes of the mouse t haplotype (1). This complex is responsible for the transmission ratio distortion phenomenon, in which the chromosomes of heterozygous +/t males are preferentially segregated so that the t haplotype is transmitted to >95% of the offspring (1). Transmission ratio distortion of t haplotypes involves dysfunction of both flagellar inner and outer dynein arms (2). Tctex2 might be a light chain of flagellar outer arm dynein and the abortive phosphorylation of Tctex2/outer arm dynein, light chain might be related to the less progressive movement of sperm (3). Tctex2 maps to the t-complex and encodes a membrane-associated protein found exclusively on the sperm tail (4,5).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of Tctex2 long and short isoforms of mouse, rat and human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 1-191 representing full length Tctex2 of mouse origin
Tissue Specificity
epitope corresponding to amino acids 1-191 representing full length Tctex2 of mouse origin