Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.| Product Name | MAGE-A11 Antibody (N-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-A11 (melanoma antigen family A, 11), also known as MAGE11, MAGE-11, MAGEA-11 or CT1.11 (cancer/testis antigen 1.11), is a 429 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one MAGE domain. Expressed in a variety of tumors, including melanoma, breast cancer and lung cancer, MAGE-A11 functions as an androgen receptor (AR) co-regulator that modulates the interdomain of AR, thereby increasing its activity. Through its regulation of AR, MAGE-A11 is thought to play an important role in embryonic development and tumor progression/transformation. Two isoforms of MAGE-A11 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFIHCELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of MAGE-A11 of human origin by IF IHC(P) and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of MAGE-A11 of human origin by IF, IHC(P) and ELISA |
| Entrez Gene | 4110 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
