Application
Western blot analysis of PLAC4 expression in HEK293 (A), HeLa (B), JEG-3 (C), JAR (D), Jurkat (E) and A-431 (F) whole cell lysates.| Product Name | PLAC4 Antibody (S-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | PLAC4 (placenta-specific 4), also known as D21S418E, is a 150 amino acid protein that is expressed in maternal plasma by placental syncytiotrophoblast and choriocarcinoma cells. PLAC4 is fetal derived, therefore it is specifically expressed during pregnancy and clears from maternal plasma within 24 hours after delivery. The PLAC4 gene is located on chromosome 21 and has four single nucleotide polymorphisms (SNPs) in its transcribed regions. This allows for PLAC4 to be a target gene in the noninvasive prenatal detection of trisomy 21 by allelic ratio analysis of placental expressed mRNA transcripts in maternal plasma. In a heterozygous fetus, both alleles of an SNP should be represented equally. An imbalance in allele frequency, giving a 2:1 ratio, suggests an additional copy of chromosome 21 and thus detection of trisomy 21. In addition, PLAC4 may be a useful target in the prenatal detection of Down syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PLAC4 of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of PLAC4 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of PLAC4 of human origin |
| Entrez Gene | 191585 |
|---|
Application
Western blot analysis of PLAC4 expression in HEK293 (A), HeLa (B), JEG-3 (C), JAR (D), Jurkat (E) and A-431 (F) whole cell lysates.| Application Notes | recommended for detection of PLAC4 of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
