| Product Name | ATMIN Antibody (H-243) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ATMIN (ATM/ATR-substrate Chk2-interacting Zn2+-finger protein) is a DNA damage response protein. It functions as a scaffold protein in the lesion-specific Rad51 focus forming pathway. In response to DNA methylating agents and persistent single stranded DNA gaps, ATMIN forms Rad51-containing foci for DNA repair. The ATMIN foci are MLH1-dependent. ATMIN is similar in structure and function to Mdt1. It consists of an N-terminal nucleic acid binding domain, a nuclear localization signal and a C-terminal SQ/TQ cluster domain (SCD). ATMIN interacts with the Forkhead-associated (FHA) domain of Chk2 via its SCD and may be a substrate for ATM/ATR kinase. A lack in functional ATMIN results in impaired Rad51 focus formation and leads to increased DNA damage-induced apoptosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ATMIN of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 581-823 mapping at the C-terminus of ATMIN of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 581-823 mapping at the C-terminus of ATMIN of human origin |
| Entrez Gene | 23300 |
|---|
| Application Notes | recommended for detection of ATMIN of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
