| Product Name | p-C3G Antibody (Tyr 514) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | C3G (RAPGEF1, Rap guanine nucleotide exchange factor (GEF) 1, GRF2) is a human guanine nucleotide releasing protein for Ras protein. C3G belongs to the adaptor-type Src homology (SH2)-containing molecules. SH2 domains are globular protein modules present in a large variety of functionally distinct proteins. Src family kinases or pervanadate treatment induces phosphorylation of C3G on Tyrosine-504. C3G can interact with Hck and undergo tyrosine phosphorylation by treatment of human myelomonocytic THP-1 cells with mercuric chloride. C3G mRNA is ubiquitous in human adult and fetal tissues. C3G-dependent activation of Rap1 is required for adhesion and spreading of embryonic fibroblasts and for the early embryogenesis of the mouse. The human C3G gene encodes several transcript variants. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| blocking peptide, sc-32621 P | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Tyr 514 phosphorylated C3G of mouse origin by WB IF and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of Tyr 514 phosphorylated C3G of mouse origin by WB, IF and ELISA |
| Entrez Gene | 107746 |
|---|
| Application Notes | blocking peptide, sc-32621 P |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
