| Modification Notes |
Kynurenine aminotransferases belong to the class-I pyridoxal-phosphate-dependent aminotransferase family and contain the members KAT I, KAT II, and KAT III. Kynurenine aminotransferases belong to the class-I pyridoxal-phosphate-dependent aminotransferase family and contain the members KAT I, KAT II, and KAT III. KAT II is a mitochondrial protein involved in lysine degradation. KAT II is expressed highly in liver, but can also be detected in heart, brain, kidney, pancreas, ovary, and testis. Like KAT I, KAT II functions in the catalysis of the reaction L-2-aminoadipate + 2-oxoglutarate --> 2-oxoglutaramate + L-glutamate. KAT II is thought to function as a homodimer. |