Interferon-stimulated gene (ISG20) protein is a 3’ to 5’ exonuclease that specifically targets single-stranded RNA for degradation. Located in promyelocytic leukemia (PML) nuclear bodies, ISG20 is present in peripheral blood leukocytes, spleen, thymus, colon and lung tissues. Constitutive expression of ISG20 confers resistance to vesicular stomatitis virus (VSV), influenza virus, and encephalomyocarditis virus (EMCV). In addition to providing antiviral protection, ISG20 may mediate estrogen influence on cellular proliferation and differentiation.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of ISG20 of human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 101-150 mapping within an internal region of ISG20 of human origin
Tissue Specificity
epitope corresponding to amino acids 101-150 mapping within an internal region of ISG20 of human origin