| Modification Notes |
Cutaneous T cell lymphomas (CTCL) represent a group of malignancies that originate from CD4-T lymphocytes and manifest on the skin. CTCL is a general term for several neoplasms including mycosis fungoides, T cell leukemia/ lymphoma and pagetoid reticulosis, all of which are very difficult to treat in the advanced stages. CTAGE3 (cutaneous T cell lymphoma associated-antigen 3) is a member of the cancer/testis antigen family of proteins and is expressed in normal tissues including colon, mammary gland, ovary, placenta, stomach and testis, as well as several fetal tissues. CTAGE3 is a 158 amino acid protein that has been detected in mycosis fungoides tissues and T-zone lymphomas. This evidence suggests a potential role for CTAGE3 in the immunotherapy of cutaneous T-cell lymphomas and other malignancies. |