| Product Name | Myosin Ia Antibody (M-125) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Troponin facilitates interaction between Actin and Myosin by binding to Ca2+. Troponin is made up of at least two subunits, which are divergent in cardiac muscle, fast skeletal muscle and slow skeletal muscle. Myosin is a hexamer of two heavy chains (MHC) and four light chains (MLC) that interacts with Actin to generate the force for diverse cellular movements, including cyto-kinesis, phagocytosis and muscle contraction. Myosin Ia (MYO1A) is also designated Brush border myosin I or myosin I heavy chain. MYO1A, the gene encoding for the Myosin Ia protein, localizes to chromosome 12q13-q15. Mutations in the MYO1A gene may cause autosomal dominant nonsyndromic sensorineural deafness (DFNA). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Myosin Ia of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 726-850 mapping near the C-terminus of Myosin Ia of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 726-850 mapping near the C-terminus of Myosin Ia of mouse origin |
| Entrez Gene | 4640 |
|---|
| Application Notes | recommended for detection of Myosin Ia of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
