| Modification Notes |
Mesothelin is a glycosylphosphatidylinositol-linked cell-surface molecule expressed in the mesothelial lining of the body cavities and in many tumor cells. Mesothelin is a tumor antigen on the surface of human ovarian cancers and mesotheliomas. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid, and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. In adult mouse tissues the mesothelin transcript is present in lung, heart, spleen, liver, kidney and testis. |