| Product Name | ABCG5 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 352-651 of ABCG5 of human origin |
| Modification Notes | ABCG5 (also designated Sterolin-1) is a member of the evolutionarily conserved family of ATP-binding cassette (ABC) transporters. ABC transporters couple the energy of ATP hydrolysis to the translocation of various molecules across biological membranes. These proteins contain characteristic ATP-binding domains at the amino-terminus and a transmembrane domain in the carboxy-terminus, which forms a channel-like structure for transport. The ABCG5 gene maps to human chromosome 2p21 and is highly expressed in liver and intestine. ABCG5 and a highly homologous gene, ABCG8 (also designated Sterolin-2), are thought to regulate the uptake of dietary cholesterol and block the absorption of plant and shellfish sterols. Mutations in either ABCG5 or ABCG8 lead to sitosterolemia, a rare autosomal recessive disorder characterized by hyperabsorption of all sterols, including cholesterol and plant and shellfish sterols. Patients with this disease are hypercholesterolemic and frequently develop xanthomas, accelerated atherosclerosis and premature coronary artery disease. Therefore, ABCG5 is a critical component of the sterol transport pathway. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ABCG5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 352-651 of ABCG5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 352-651 of ABCG5 of human origin |
| Entrez Gene | 64240 |
|---|
| Application Notes | recommended for detection of ABCG5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
