Application
Immunofluorescence staining of formalin-fixed Hep G2 cells showing cytoplasmic localization.| Product Name | δ-catenin Antibody (H-160) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The å-, ∫-, ©-, and ∂ -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. å-catenin interacts with E-cadherin associated protein and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. ∫-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. ∫-catenin also complexes with the tumor suppressor protein APC. ©-catenin, also known as plakoglobin, is a protein that binds å-catenin and N-cadherin. ∂-catenin interacts with presenilin 1 and is expressed in the brain. The gene encoding ∂-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding ∂-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. In addition, the transmembrane phosphatase PTPm associates with catenin/ cadherin complexes and may regulate complex signaling. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of &delta-catenin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1031-1190 mapping near the C-terminus of &delta -catenin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1031-1190 mapping near the C-terminus of δ-catenin of human origin |
| Entrez Gene | 1501 |
|---|
Application
Immunofluorescence staining of formalin-fixed Hep G2 cells showing cytoplasmic localization.| Application Notes | recommended for detection of &delta-catenin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
