| Product Name | TLX3 Antibody (H-55) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Members of the TLX homeobox gene family are expressed in the developing hindbrain; specifically, the TLX3 gene is expressed in the developing dorsal and ventral medulla oblongata. The TLX3 gene is required for formation of first-order relay visceral sensory neurons in the brainstem. Development of most nor/adrenergic centers is compromised in both TLX3- and Phox2b-deficient mice. The TLX3 and Phox2 proteins have independent functions in specifying the nor/adrenergic phenotype. TLX3-deficient newborn mice have a high rate of respiration, a decreased duration of inspiration and frequent apnea; they die shortly after birth from central respiratory failure. In both chick and mouse embryos, TLX3 expression occurs in two longitudinal stripes of postmitotic neurons in the developing hindbrain and spinal cord. The human TLX3 gene maps to chromosome 5q34-q35. Implicated in T-ALL (T-cell acute lymphoblastic leukemia), the t(5:14)(q35;q32) translocation increases transcription of the TLX3 gene. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of TLX3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 31-85 mapping near the N-terminus of TLX3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 31-85 mapping near the N-terminus of TLX3 of human origin |
| Entrez Gene | 30012 |
|---|
| Application Notes | recommended for detection of TLX3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
