Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human bone marrow tissue showing cytoplasmic staining of hematopoietic cells.Application
Western blot analysis of IL-21R expression in non-transfected 293T: (A), mouse IL-21R transfected 293T: (B) and Raji (C) whole cell lysates.Application
Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.| Product Name | IL-21R Antibody (H-213) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 20-232 mapping near the N-terminus of IL-21R of human origin |
| Modification Notes | The IL-21 receptor (also designated IL-21R, NILR or novel interleukin receptor) is a type I cytokine receptor that forms a complex with the cytokine receptor g chain, g(c), and mediates IL-21 signaling. IL-21R is present on the surface of natural killer, B and T cell populations with high levels in spleen and thymus. IL-21 and IL-21R influence lymphoid proliferation and early lymphoid development in the transition between innate and adaptive immunity. Tumor necrosis factor (TNF) upregulates IL-21R, and combinations of TNF and IL-21 can have synergistic effects on myeloma cell proliferation through pathways involving phosphorylation of JAK1, Stat3, and Erk1/2. The human IL-21R gene maps to chromosome 16p11 and encodes a 538 amino acid protein that is closely related to human IL2RB and shares 62% sequence identity to mouse Il21r. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of IL-21R of mouse, rat and human origin by WB, IP, IF, IHC(C) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 20-232 mapping near the N-terminus of IL-21R of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 20-232 mapping near the N-terminus of IL-21R of human origin |
| Entrez Gene | 50615 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human bone marrow tissue showing cytoplasmic staining of hematopoietic cells.
Application
Western blot analysis of IL-21R expression in non-transfected 293T: (A), mouse IL-21R transfected 293T: (B) and Raji (C) whole cell lysates.
Application
Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.| Application Notes | recommended for detection of IL-21R of mouse, rat and human origin by WB, IP, IF, IHC(C) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
