Application
Western blot analysis of MAdCAM-1 expression in rat spleen tissue extract.| Product Name | MadCAM-1 Antibody (M-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 106-405 mapping at the C-terminus of MadCAM-1 of mouse origin |
| Modification Notes | The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules (“homing receptors”) recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer’s patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin å4/∫7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MadCAM-1 of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 106-405 mapping at the C-terminus of MadCAM-1 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 106-405 mapping at the C-terminus of MadCAM-1 of mouse origin |
| Entrez Gene | 17123 |
|---|
Application
Western blot analysis of MAdCAM-1 expression in rat spleen tissue extract.| Application Notes | recommended for detection of MadCAM-1 of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
