| Modification Notes |
NYAP2 (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2) is a 653 amino acid protein that is a member of the NYAP family and activates PI3K. At the same time of PI3K activation, NYAP2 recruits the WAVE1 complex near PI3K and aids in neuronal morphogenesis by participating in cytoskeletal remodelization. NYAP2 interacts with ACOT9, PIK3R2 and ARHGAP26, as well as components of CYFIP1 and NAP125. Existing as three alternatively spliced isoforms, NYAP2 is post-translationally phosphorylated at multiple residues. The gene encoding NYAP2 maps to human chromosome 2, which encodes over 1,400 genes and comprises approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alström syndrome. |