Application
Antibodies tested include Bek (C-8): (A) and Bek (C-17): (B).Application
Antibodies tested include Bek (C-17): (A), FGFR-3 (C-15): (B) and FGFR-4 (C-16): (C). Kindly provided by Leslie Gold.Application
Western blot analysis of Bek transfected (A) and non-transfected control (B) NIH/3T3 whole cell lysates. Cells kindly provided by D. Bottaro.| Product Name | Bek Antibody (C-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within a C-terminal cytoplasmic domain of Bek of human origin |
| Modification Notes | Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor (or FGFR-2), FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Bek (also designated K-sam) maps to chromosome 10q26 and is alternatively spliced to produce several isoforms. Heterogeneous mutations in Bek are associated with a range of craniosynostosis syndromes including Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome and Apert syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISAChIP |
| recommended for detection of Bek of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within a C-terminal cytoplasmic domain of Bek of human origin |
|---|---|
| Tissue Specificity | epitope mapping within a C-terminal cytoplasmic domain of Bek of human origin |
| Entrez Gene | 2263 |
|---|
Application
Antibodies tested include Bek (C-8): (A) and Bek (C-17): (B).
Application
Antibodies tested include Bek (C-17): (A), FGFR-3 (C-15): (B) and FGFR-4 (C-16): (C). Kindly provided by Leslie Gold.
Application
Western blot analysis of Bek transfected (A) and non-transfected control (B) NIH/3T3 whole cell lysates. Cells kindly provided by D. Bottaro.| Application Notes | recommended for detection of Bek of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
