| Modification Notes |
Myosins are highly conserved, ubiquitously expressed proteins that interact with Actin to generate the force for cellular movements. The human genome encodes over 40 different Myosin genes which are divided into distinct classes, the most notable of which are the conventional Myosins (class II) and the unconventional Myosins (classes I and III through XVIII). Myosin XVA, also designated unconventional Myosin-15 or MYO15A, is a 3,530 amino acid cytoplasmic protein that is required for actin organization in hair cells of the cochlea. While highly expressed in pituitary, Myosin XVA is found at lower levels in placenta, lung, liver, kidney, skeletal muscle and pancreas. Myosin XVA contains one FERM domain, an SH3 domain, three IQ domains, two MyTH4 domains and a single Myosin head-like domain. |