Application
Immunofluorescence staining of methanol-fixed untransfected (A) and human GRHPR transfected HEK 293 cells (B).| Product Name | GRHPR Antibody (H-115) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 86-200 mapping within an internal region of GRHPR of human origin |
| Modification Notes | GRHPR (glyoxylate reductase/hydroxypyruvate reductase), also known as GLXR, is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. Localizing to the cytosol, GRHPR is ubiquitously expressed with highest expression levels found in liver. Functioning as a homodimer, GRHPR plays a role in metabolism by removing the highly reactive two carbon acid by-product glyoxylate through a reduction reaction which yields glycolate. In addition, GRHPR contains hydroxypyruvate reductase activity and D-glycerate dehydrogenase activity. Mutations in the gene encoding GRHPR that impair its ability to reduce glyoxylate can result in primary hyperoxaluria type II (PH2 or HP2), a disease characterized by the formation of kidney stones, increased urinary excretion of L-glycerate and oxalate and renal failure. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of GRHPR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 86-200 mapping within an internal region of GRHPR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 86-200 mapping within an internal region of GRHPR of human origin |
| Entrez Gene | 76238 |
|---|
Application
Immunofluorescence staining of methanol-fixed untransfected (A) and human GRHPR transfected HEK 293 cells (B).| Application Notes | recommended for detection of GRHPR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
